Serum osteopontin is a novel tumor marker surrogating SOX9-positive cancer stem cells in human hepatocellular carcinoma

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SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma

The current lack of cancer stem cell (CSC) markers that are easily evaluated by blood samples prevents the establishment of new therapeutic strategies in hepatocellular carcinoma (HCC). Herein, we examined whether sex determining region Y-box 9 (SOX9) represents a new CSC marker, and whether osteopontin (OPN) can be used as a surrogate marker of SOX9 in HCC. In HCC cell lines transfected with a...

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ژورنال

عنوان ژورنال: HPB

سال: 2016

ISSN: 1365-182X

DOI: 10.1016/j.hpb.2016.02.531